Cowell said: "I would rather take a bath, fill it with vinegar, cut myself a thousand times, immerse myself slowly for an hour, than work with her."
Katie Hopkins is not likely to get a spot on the Britain's Got Talent judging panel - if Simon Cowell has anything to do with it.
Asked if there would ever be space for the outspoken Apprentice and Celebrity Big Brother star on the judging panel of the ITV talent show, Cowell said: "I would rather take a bath, fill it with vinegar, cut myself a thousand times, immerse myself slowly for an hour, than work with her. So the answer is no."
Cowell was talking at the Elle Style Awards in London, where he won the outstanding contribution to entertainment accolade.
He joked that he would keep his award in his "aircraft hangar" where he keeps his awards.
Meanwhile, he said his advice to One Direction was to "stay together" and asked if he thought talent show acts get snubbed at the Brit Awards, said: "Sometimes, but I think we've kind of broken the mould with that.
"I don't get kind of like, upset, about it. It's all about having hit records. If you can get awards as well it's brilliant, but I have no complaints."
Loudmouth Katie has threatened to be "Miss Nasty" if she was hired for the show.
She insisted: "There is a role for a Miss Nasty on any panel. We don't have any good Miss Nasties at the moment because everyone wants to be sweet like Cheryl Cole.
"They want to be loved. It would be good to have someone different. There's absolutely more TV coming up for me."
While the judging panel will remain as Simon, Amanda Holden, David Walliams and Alesha Dixon when BGT returns later this year for its ninth series, it seems Amanda could leave once she celebrates its tenth run next year .
"Every year Britain’s Got Talent feels fresh. It always feels like a new job to me," she said.
“But next year will be my tenth year on the show and I would love to make it to ten and then call it a day. I think ten years is an amazing feat.
“After that I want a nice big clock and a holiday in the sun as a retirement package.”